Treatment depends on the type of glomerulonephritis. When it is caused by an infection, antibiotics may be given. Many treatments can cause serious side effects because they attack the whole immune system. Treatment may include drug therapy, such as ACE (angiotensin converting enzymes) inhibitors, ARBs (Angiotensin II receptor agonists), diuretics, calcium channel blockers and beta blockers.

Severe forms of glomerulonephritis are treated with medications to control high blood pressure, as well as changes in diet to reduce the work of the kidneys. The patients may be advised to drink less fluid and to avoid certain drinks such as alcohol and drinks with a lot of sodium chloride (salt) and potassium.

In some cases glomerulonephritis becomes a chronic condition that lasts for years and progresses to end-stage renal failure. Treatment options of such cases include dialysis and kidney transplant.