She started her film career in 2001 with Lohithadas's Malayalam movie 'Sutradharan' with Dileep in the lead. Though the film failed to make a mark at the box office, it brought her into the spotlight. It was her Tamil debut 'Run' (2002) a huge hit in Tamil Nadu directed by Lingusamy opposite Madhavan, that turned her luck for the better. Her subsequent films showcased her talent as an actress and soon established her as an actor to reckon with.

Meera has acted with top directors of Malayalam films like Lohithadas, Sathyan Anthikkad and Kamal. She got some real attention in movies like 'Kasthoorimaan' (2003) where she enacted both comedy and sentiments with equal fervor. And in Kamal's 'Swapnakoodu' (2003)-among the five main characters, one who scored the most was again Meera. The same year, her role in T.V. Chandran's 'Padam Onnu Oru Vilapam' got her the National award for Best Actress. In 'Perumazakkalam' (2004) she gave a soul stirring performance as Raziya, definitely one of her best roles till date. In the movie 'Achuvinte Amma'(2005), she has enacted the young, adorable character Achu, with extraordinary ease that she seemed to live the character, instead of acting. She paired with Malayalam superstars-Mohanlal in 'Rasathantram' (2006) and recently with Mammootty in 'Ore Kadal' (2007).

Her main plus points are facial expressions and spontaneity- in acting and dialogue delivery. Over the years she has matured as an actor and she believes in doing worthy roles and being part of good Cinema. She is being sought out by reputed film makers all over the South. Her notable films in Tamil are Mani Ratnam's 'Aayitha Ezhuthu' (2004), Lohitadas's 'Kasthoori Maan' (2005), a remake of the Malayalam version. 'Sandakozhi' (2005) completed within 200 days was a big hit as was S.S Stanleys 'Mercury Pookal' (2006) where her down to earth role was very much appreciated.

She entered Telugu cinema in 2004. Some of her Telugu films are 'Ammayi Bagundi' (2004), 'Gudumba Shankar' (2004), 'Bhadra' (2005), 'Maharadhi' (2007) etc. 'Mourya' (2004) with Puneet Rajkumar, marked Meera's debut in Kannada. Her Kannada film, 'Arrasu' (2006), was also a success.

She has been honoured with several awards for her portrayals. National Film Award and State Award for Best Actress in 2004 for her role in 'Padam Onnu Oru Vilapam'(2003). Filmfare Award thrice for Best Female Debut Actress for 'Run' in 2003, Best Actress in 2004 for 'Padam Onnu Oru Vilapam' and Best Actress in 2006 for 'Achuvinte Amma'. She won the Lux-Asianet Film Award for two consecutive years in 2003 and 2004 for her films 'Perumazhakkalam' and 'Achuvinte Amma' respectively. And she was also honoured by Tamil Nadu State, by recognizing her as the Best Actress (Special Award) in 2006 for 'Kasthooriman' (Tamil).